This is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions). This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists. * Includes clinical perspective boxes in each chapter that make connections between molecular processes and disease states, between biochemistry and drug discovery enabling students to better understand neurological diseases * Presents cutting-edge advances in neuroscience in context of principles of brain chemistry and biology * Companion Web site features animations to illustrate critical biochemical processes