Electrospray and MALDI Mass Spectrometry Fundamentals, Instrumentation, Practicalities, and Biological Applications
by Cole, Richard B.Edition: 2nd
Format: Hardcover
Pub. Date: 2010-04-26
Publisher(s): Wiley
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Summary
Electrospray Mass Spectrometry: Fundamentals, Instrumentation, and Applications, Second Edition is an extensively updated version of the original guide. It explores the coupling of electrospray ionization to various mass spectrometers, including quadrupole ion trap, magnetic, time-of-flight, and Fourier transform ion cyclotron resonance instruments. It introduces new fields (proteomics, metabolomics, etc.) that have flourished largely due to electrospray mass spectrometry. Encompassing fundamentals, instrumentation, applications, and analytical aspects, this is a key reference for researchers using electrospray mass spectrometry and for scientists in the biotech and pharmaceutical industries.
Author Biography
Richard B. Cole, PhD, is a University Research Professor in The Department of Chemistry at The University of New Orleans. He has spent more than twenty-five years working in the field of mass spectrometry. His research interests include analytical/bio-organic chemistry as well as fundamentals and applications of mass spectrometry, with a focus on the development of novel analytical methods employing electrospray and MALDI.
Table of Contents
| Foreword: Desorption Ionization and Spray Ionization: Connections and Progress | p. vii |
| Foreword to the First Edition | p. xxi |
| Preface | p. xxvii |
| Contributors | p. xxix |
| Fundamentals of ES | |
| On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS) | p. 3 |
| Selectivity in Electrospray Ionization Mass Spectrometry | p. 49 |
| Electrochemistry of the Electrospray Ion Source | p. 75 |
| ESI Source Design | p. 123 |
| Fundamentals of MALDI | |
| MALDI Ionization Mechanisms: and Overview | p. 149 |
| The Development of Matrix-Assisted Laser Desorption/Ionization Sources | p. 185 |
| A Comparison of MALDI Matrices | p. 215 |
| MALDI Imaging Mass Spectrometry | p. 245 |
| Es and MALDI Coupling to Mass Spectrometry Instrumentation | |
| Coupling ESI and MALDI Sources to the Quadrupole Mass Filter, Quadrupole Ion Trap, Linear Quadrupole Ion Trap, and Orbitrap Mass Analyzers | p. 265 |
| Time-of-Flight Mass Spectrometry | p. 345 |
| Fourier Transform Ion Cyclotron Resonance and Magnetic Sector Analyzers for ESI and MALDI | p. 365 |
| Ion Mobility-Mass Spectrometry | p. 411 |
| Practical Aspects of ES and MALDI | |
| ESI, APCI, and MALDI a Comparison of the Central Analytical Figures of Merit: Sensitivity, Reproducibility, and Speed | p. 443 |
| Charge State Distributions in Electrospray and MALDI | p. 491 |
| Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization | p. 535 |
| Ion Activation Methods for Tandem Mass Spectrometry | p. 571 |
| Dissociation of Even-Electron Ions | p. 631 |
| Biological Applications of ES and MALDI | |
| The Role of Mass Spectrometry for Peptide, Protein, and Proteome Characterization | p. 685 |
| Carbohydrate Analysis by ESI and MALDI | p. 723 |
| Applications of ESI and MALDI to Lipid Analysis | p. 771 |
| In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery | p. 799 |
| Index | p. 825 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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