Gut Flora, Nutrition, Immunity and Health

by ; ;
Edition: 1st
Format: Hardcover
Pub. Date: 2003-07-18
Publisher(s): Wiley-Blackwell
List Price: $374.26

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Summary

Some foods, as well as contributing essential nutrients to the body, also contain additional components that improve disease resistance and general health status over and above that induced by ingestion of conventional foods. The so-called functional foods, and prebiotics and probiotics exemplify the relationship that exists between nutrition, the gut (the largest element of the body's immune system) and its flora, immunology and health. This important book contains chapters covering the basic principles of nutrition, gut microecology and immunology, as well as chapters which discuss the way in which this knowledge may be used to explain the positive and negative effects of food consumption, metabolism, probiotics and prebiotics. Food hypersensitivity and allergic reactions, carcinogenesis, and the role of nutrition in the reduced immunity of the aged are also discussed in detail. The editors of this exciting and informative book, who between them have a vast wealth of knowledge of the area, have drawn together and carefully edited international contributions from many well known and respected workers in the area. Gut Flora, Nutrition, Immunity and Health provides essential information for a range of professionals including nutritionists, dietitians, food scientists, microbiologists, gastroenterologists, immunologists and all personnel working in the development and use of functional foods and supplements, prebiotics and probiotics. Libraries in universities and research establishments where these subjects are studied and taught, and pharmaceutical and food companies should have multiple copies of this very useful book on their shelves. Roy Fuller is a consultant in gut microecology, based in Reading, UK; Gabriela Perdigon is based at the Centro de Referencia para Lactobacillus (CERELA) and at the Faculty of Biochemistry, Chemistry and Pharmacy of Tucuman University, Argentina.

Author Biography

Roy Fuller is the editor of Gut Flora, Nutrition, Immunity and Health, published by Wiley.

Gabriela Peridigón is the editor of Gut Flora, Nutrition, Immunity and Health, published by Wiley.

Table of Contents

Preface xi
Acknowledgements xii
The Intestinal Microflora
1(23)
G.W. Tannock
From Petri dish to polyacrylamide gel
1(6)
Catalogues show diversity
7(1)
A phoenix arises
7(5)
Is it all the same in the end?
12(2)
The formative years
14(1)
Rules and regulations, but mind your language
15(9)
Food and the Large Intestine
24(28)
S. Macfarlane
G.T. Macfarlane
The large intestine
24(2)
Interactions of the microflora with the host
26(1)
Effect of diet on the colonic microflora
26(5)
Diet and bacterial species composition in the large intestine
26(2)
Diet and bacterial metabolism
28(2)
Intestinal bacteria and vitamins
30(1)
Bacterial growth substrates in the large intestine
31(1)
Breakdown of complex carbohydrates by intestinal bacteria
32(3)
Protein breakdown by gut microorganisms
35(4)
Toxological implications of amino acid fermentation
36(2)
Effects of carbohydrate on amino acid fermentation
38(1)
Short-chain fatty acids
39(2)
Effect of diet on SCFA production
40(1)
In vitro studies on SCFA production
40(1)
SCFA and cell metabolism
41(1)
SCFA and colon cancer
41(1)
Lactate formation by gut microorganisms
41(11)
The Health Benefits of Probiotics and Prebiotics
52(25)
G.R. Gibson
R.A. Rastall
R. Fuller
Summary
52(1)
Introduction
52(3)
Probiotics
55(4)
Composition of probiotic preparations
55(2)
Tracking probiotics through the gut
57(2)
Prebiotics
59(7)
Oligosaccharides as prebiotics
59(1)
Lactulose
60(1)
Inulin and fructooligosaccharides
60(1)
Galactooligosaccharides
61(1)
Soybean oligosaccharides
62(1)
Lactosucrose
62(1)
Isomaltooligosaccharides
63(1)
Glucooligosaccharides
63(1)
Xylooligosaccharides
64(1)
Current status
64(1)
Persistence of the prebiotic effect to distal regions of the colon
65(1)
Anti-adhesive activities against pathogens and toxins
65(1)
Targeted prebiotics
65(1)
Attenuative properties
66(1)
Defined health outcomes of probiotics and prebiotics
66(3)
Improved tolerance to lactose
66(1)
Protection from gastroenteritis
67(1)
Coronary heart disease
67(1)
Colon cancer
68(1)
Vitamin synthesis
68(1)
Irritable bowel syndrome
68(1)
Improved digestion and gut function
68(1)
Immunomodulation
69(1)
Mineral bioavailability
69(1)
Conclusions
69(8)
Intestinal Microflora and Metabolic Activity
77(22)
A. Perez Chaia
G. Oliver
Dietary carbohydrates
77(2)
Bacterial fermentation
79(3)
SCFA production
82(2)
SCFA and electrolytes absorption
84(3)
Colonic metabolism
87(1)
Physiological consequences of SCFA absorption
87(2)
Probiotics and the intestinal metabolism of carbohydrates
89(10)
The Role of the Immune System
99(38)
C.M. Riera
M. Maccioni
C.E. Sotomayor
Overview of the immune system
99(16)
Introduction
99(1)
Innate immune response
100(3)
Early induced immune response
103(1)
Adaptative immune response
104(1)
B lymphocytes and the immunoglobulins
104(5)
T lymphocytes and the T cell receptor complex
109(1)
APCs and the MHC molecules
110(5)
Education of lymphocytes in the primary lymphoid organs
115(4)
Education of T lymphocytes in the thymus
115(2)
Education of B lymphocytes in the bone marrow
117(2)
The immune system functioning
119(11)
Peripheral lympoid tissues, a place where lymphocytes meet the antigen
119(1)
Lymphocyte traffic
120(1)
Activation of T cells
121(1)
Cell-mediated immune response: generation of armed effector T cells
122(1)
Generation of Th1 and Th2 cells
122(2)
Cytotoxic T cells
124(1)
Humoral immune response
125(1)
Activation of B cells in the secondary lymphoid organs
125(5)
Kinetics of the immune response
130(1)
Endogenous regulation of the immune response
130(7)
Tolerance to T cell repertoire
131(1)
Tolerance to B cell repertoire
132(1)
Immunoregulation
133(4)
Behaviour of the Immune System in Eating Disorders
137(18)
A. Marcos
E. Nova
S. Lopez-Varela
Relationship between nutrition and the immune system
137(9)
The defence of the organism
137(1)
Immune system behaviour under malnutrition
138(1)
Effects of micronutrients on the immune system
139(4)
Antioxidant vitamins
143(3)
The immune system in eating disorders
146(3)
Eating disorders as a clear example of malnutrition
146(1)
Cytokine participation over the lack of infection in eating disorders
146(1)
The interrelationship between leptin and cytokines
147(2)
Conclusions
149(6)
Mucosal Immune System and Malnutrition
155(23)
M.E. Roux
N.H. Slobodianik
P. Gauffin Cano
G. Perdigon
Mucosal immunity
155(1)
Introduction
155(1)
Organized mucosal lymphoid tissues
156(1)
Antigen uptake
156(4)
Role of epithelial, toll-like receptors and dentritic cells
156(4)
Tolerance to food
160(1)
Effect of nutritional factors on the microenvironment of mucosal immune system
160(1)
Nutrition and immunity
161(5)
Nutritional effects on immune mechanisms
161(1)
Essential amino acid deficiency and immune response
162(1)
Nutritional deficiencies and mucosal immune defence systems in animals
163(3)
Probiotics in malnutrition
166(1)
Introduction
166(1)
Protein malnutrition and immune response
167(1)
Effects of probiotic addition to a renutrition diet
168(10)
Immune Activation Versus Hyporesponsiveness and Tolerance in the Gut
178(23)
J. Chin
A. Mullbacher
Introduction
178(1)
Innate and adaptative immunity
179(1)
Antigen and the T cell response
180(1)
Antigen-presenting cells in the GIT
181(1)
T cell function in the GIT -- the CD4+ population
181(2)
γδ T cells
183(1)
Turnover of T cells
184(1)
Intestinal epithelial cells
184(1)
Peyer's patches -- suppression of T cell responsiveness
185(2)
Probiotic bacteria -- a biological role as live or dead organisms
187(1)
Immune activation by probiotic bacteria feeding
187(5)
Probiosis -- is it Gram-positive versus Gram-negative bacteria or is it live versus dead bacteria?
192(3)
Summary and perspective
195(6)
Food Hypersensitivity and Allergic Diseases
201(7)
R.K. Chandra
Introduction
201(1)
Immunological mechanisms
201(1)
Food allergens
202(1)
Clinical manifestations
202(2)
Identification of high risk infants for prevention
204(1)
Preventive measures
204(2)
Breast feeding
204(1)
Hydrolysed formulas
205(1)
Other measures
206(1)
Management of food allergy
206(2)
Nutritional and Microbial Modulation of Carcinogenesis
208(29)
R. Hughes
I. Rowland
Introduction
208(1)
Bacteria and cancer overview
209(2)
Bacterial metabolites
211(6)
Enzyme activities
211(1)
β-glucuronidase and β-glycosidase
211(1)
Enzymic hydrolysis of plant flavonoids
212(1)
Nitroreductase and nitrate reductase
213(1)
Metabolism of heterocyclic amines
213(1)
Metabolism of sulphur-containing compounds
214(1)
Secondary bile acids
215(1)
Fecapentaenes
216(1)
Reduced exposure to toxic compounds
217(1)
Formation of toxic and protective agents during fermentation
217(3)
Carbohydrate fermentation
218(1)
Short chain fatty acids
218(1)
Products of colonic protein fermentation
219(1)
Probiotics, prebiotics and cancer
220(17)
The Role of Nutrition in Immunity of the Aged
237(33)
S. Walrand
M.-P. Vasson
B. Lesourd
Introduction
237(1)
Aging and immune function
238(10)
Innate immune system
238(1)
Age-related changes in skin and mucous barriers
238(1)
Age-related changes in phagocytic cells
238(5)
Age-related changes in natural killer cells
243(1)
Acquired immune system
244(1)
Age-related involution of thymic function
244(1)
Quantitative and qualitative changes in T cell subpopulations in the elderly
244(2)
Age-related changes in T cell function
246(1)
Changes in B cell number and function in the elderly
247(1)
Nutritional regulation of immune function of the aged
248(10)
Effect of protein-energy malnutrition on immune responses in aged people
248(1)
Alterations in polymorphonuclear functions during PEM in the elderly
248(2)
Alterations in monocyte/macrophage functions during PEM in the elderly
250(1)
Alterations in T-cell mediated immunity during PEM in the elderly
250(2)
Alterations in B-cell mediated immunity during PEM
252(1)
Immune response during nutritional recovery in undernourished elderly persons
252(1)
Influence of nutritional recovery on PMN function in old age
252(1)
Influence of nutritional recovery on T cell function in old age
253(2)
Influence of nutritional supplementation in healthy well-nourished elderly subjects
255(3)
Concluding remarks
258(12)
Conclusions
270(5)
G. Perdigon
R. Fuller
Index 275

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