An Introduction to Genetic Analysis,9780716749394

An Introduction to Genetic Analysis

by ; ; ; ; ;
Edition: 8th
ISBN13: 9780716749394
ISBN10: 0716749394
Format: Hardcover
Pub. Date: 2004-04-23
Publisher(s): W. H. Freeman
List Price: $178.02

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Summary

An Introduction to Genetic Analysis (IGA)stands out from its peers in this course in that it provides a clear introduction to the techniques and experiments of scientists past and present, not just an "encyclopedia" of information. This experimental emphasis, together with a solid pedagogical framework in the chapters, provides the clearest, most cutting-edge text available. IGA is also well-known for its outstanding problem sets, an integral part of the genetics course at any school.

Table of Contents

Preface xi
Genetics and the Organism
1(26)
Genes as determinants of the inherent properties of species
3(5)
Genetic variation
8(3)
Methodologies used in genetics
11(2)
Model organisms
13(3)
Genes, the environment, and the organism
16(11)
Part I: TRANSMISSION GENETIC ANALYSIS
Patterns of Inheritance
27(46)
Autosomal inheritance
29(19)
Sex chromosomes and sex-linked inheritance
48(7)
Cytoplasmic inheritance
55(18)
The Chromosomal Basis of Inheritance
73(42)
Historical development of the chromosome theory
75(5)
The nature of chromosomes
80(10)
Mitosis and meiosis
90(6)
Chromosome behavior and inheritance patterns in eukaryotes
96(7)
Organelle chromosomes
103(12)
Eukaryote Chromosome Mapping by Recombination
115(36)
The discovery of the inheritance patterns of linked genes
117(4)
Recombination
121(3)
Linkage maps
124(7)
Using the chi-square test in linkage analysis
131(2)
Using Lod scores to assess linkage in human pedigrees
133(1)
Accounting for unseen multiple crossovers
134(17)
The Genetics of Bacteria and Their Viruses
151(34)
Working with microorganisms
153(2)
Bacterial conjugation
155(11)
Bacterial transformation
166(1)
Bacteriophage genetics
166(4)
Transduction
170(4)
Physical maps versus linkage maps
174(11)
Part II: THE RELATIONSHIP OF DNA AND PHENOTYPE
From Gene to Phenotype
185(42)
Genes and gene products
187(5)
Interactions between the alleles of one gene
192(5)
Interacting genes and proteins
197(12)
Applications of chi-square (x2) test to gene interaction ratios
209(18)
DNA: Structure and Replication
227(28)
DNA: the genetic material
229(2)
The DNA structure
231(6)
Semiconservative replication
237(3)
Overview of DNA replication
240(2)
The replisome: a remarkable replication machine
242(2)
Assembling the replisome: replication initiation
244(3)
Telomeres and telomerase: replication termination
247(8)
RNA: Transcription and Processing
255(18)
RNA
257(2)
Transcription
259(5)
Transcription in eukaryotes
264(9)
Proteins and Their Synthesis
273(28)
Protein structure
275(2)
Colinearity of gene and protein
277(1)
The genetic code
278(4)
tRNA: the adapter
282(3)
Ribosomes
285(6)
Posttranslational events
291(10)
Regulation of Gene Transcription
301(40)
Prokaryotic gene regulation
303(4)
Discovery of the lac system of negative control
307(5)
Catabolite repression of the lac operon: positive control
312(3)
Dual positive and negative control: the arabinose operon
315(1)
Metabolic pathways
316(1)
Transcriptional regulation in eukaryotes
316(6)
Chromatin's role in eukaryotic gene regulation
322(19)
Part III: GENOME STRUCTURE AND ENGINEERING
Gene Isolation and Manipulation
341(48)
Generating recombinant molecules
343(17)
DNA amplification in vitro: the polymerase chain reaction
360(2)
Zeroing in on the gene for alkaptonuria: another case study
362(2)
Detecting human disease alleles: molecular genetic diagnostics
364(2)
Genetic engineering
366(23)
Genomics
389(34)
The nature of genomics
391(1)
The sequence map of a genome
392(2)
Creating genomic sequence maps
394(4)
Using genomic sequence to find a specific gene
398(8)
Bioinformatics: meaning from genomic sequence
406(4)
Take-home lessons from the genomes
410(3)
Functional genomics
413(10)
The Dynamic Genome: Transposable Elements
423(28)
Discovery of transposable elements in maize
425(4)
Transposable elements in prokaryotes
429(5)
Transposable elements in eukaryotes
434(6)
The dynamic genome: more transposable elements than ever imagined
440(5)
Host regulation of transposable elements
445(6)
Part IV: THE NATURE OF HERITABLE CHANGE
Mutation, Repair, and Recombination
451(30)
Point mutations
453(8)
Spontaneous mutation
461(7)
Biological repair mechanisms
468(5)
The mechanism of meiotic crossing-over
473(8)
Large-Scale Chromosomal Changes
481(40)
Changes in chromosome number
483(13)
Changes in chromosome structure
496(10)
Overall incidence of human chromosome mutations
506(15)
Part V: FROM GENES TO PROCESSES
Dissection of Gene Function
521(24)
Forward genetics
523(7)
Reverse genetics
530(5)
Analysis of recovered mutations
535(2)
Broader applications of functional dissection
537(8)
Genetic Regulation of Cell Number: Normal and Cancer Cells
545(30)
The balance between cell loss and proliferation
547(1)
The cell-proliferation machinery of the cell cycle
548(4)
The machinery of programmed cell death
552(1)
Extracellular signals
553(5)
Cancer: the genetics of aberrant cell number regulation
558(8)
Applying genomic approaches to cancer research, diagnosis, and therapies
566(9)
The Genetic Basis of Development
575(36)
The logic of building the body plan
577(1)
Binary fate decisions: the germ line versus the soma
578(4)
Forming complex pattern: the logic of the decision-making process
582(1)
Forming complex pattern: establishing positional information
583(8)
Forming complex pattern: utilizing positional information to establish cell fates
591(6)
Refining the pattern
597(3)
The many parallels in vertebrate and insect pattern formation
600(2)
The genetics of sex determination in humans
602(1)
Do the lessons of animal development apply to plants?
603(2)
Genomic approaches to understanding pattern formation
605(6)
Part VI: THE IMPACT OF GENETIC VARIATION
Population Genetics
611(32)
Variation and its modulation
612(9)
Effect of sexual reproduction on variation
621(5)
Sources of variation
626(3)
Selection
629(5)
Balanced polymorphism
634(2)
Random events
636(7)
Quantitative Genetics
643(36)
Genes and quantitative traits
645(2)
Some basic statistical notions
647(2)
Genotypes and phenotypic distribution
649(2)
Norm of reaction and phenotypic distribution
651(1)
Determining norms of reaction
652(2)
The heritability of a quantitative character
654(2)
Quantifying heritability
656(8)
Locating genes
664(3)
Statistical appendix
667(12)
Evolutionary Genetics
679(28)
A synthesis of forces: variation and divergence of populations
682(3)
Multiple adaptive peaks
685(2)
Heritability of variation
687(1)
Observed variation within and between populations
688(1)
The process of speciation
689(2)
Origin of new genes
691(4)
Rate of molecular evolution
695(1)
Genetic evidence of common ancestry in evolution
696(2)
Comparative genomics and proteomics
698(9)
A Brief Guide to Model Organisms 707(16)
Appendix A: Genetic Nomenclature 723(1)
Appendix B: Bioinformatics Resources for Genetics and Genomics 724(3)
Glossary 727(22)
Answers to Selected Problems 749(14)
Index 763

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