The Merck Manual of Medical Information

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Edition: 1st
Format: Paperback
Pub. Date: 2000-09-01
Publisher(s): Pocket
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Summary

Compiled by two hundred renowned medical experts, the internationally acclaimed medical reference includes up-to-date information on heart disease, digestive disorders, cancer, nutrition, AIDS, hormonal disorders, infections, geriatric care, psychiatry, and much more. Reprint.

Table of Contents

A Guide for Readers xxiii
Understanding Medical Terms xxv
Section 1 Fundamentals 1(22)
Anatomy
1(6)
Genetics
7(5)
The Aging Body
12(3)
Death and Dying
15(8)
Section 2 Drugs 23(44)
Overview of Drugs
23(5)
Drug Administration, Distribution, and Elimination
28(3)
Pharmacodynamics
31(3)
Factors Affecting Drug Response
34(5)
Drugs and Aging
39(3)
Adverse Drug Reactions
42(4)
Compliance With Drug Treatment
46(2)
Generic Drugs
48(5)
Over-the-Counter Drugs
53(14)
Section 3 Heart and Blood Vessel Disorders 67(82)
Biology of the Heart and Blood Vessels
68(4)
Diagnosis of Heart Disease
72(7)
Abnormal Heart Rhythms
79(8)
Heart Failure
87(3)
Cardiomyopathy
90(3)
Heart Valve Disorders
93(6)
Heart Tumors
99(2)
Endocarditis
101(3)
Pericardial Disease
104(3)
Low Blood Pressure
107(4)
Shock
111(1)
High Blood Pressure
112(6)
Atherosclerosis
118(3)
Coronary Artery Disease
121(9)
Peripheral Arterial Disease
130(7)
Aortic Aneurysms and Dissection
137(4)
Venous and Lymphatic Disorders
141(8)
Section 4 Lung and Airway Disorders 149(64)
Biology of the Lungs and Airways
150(9)
Diagnostic Tests for Lung and Airway Disorders
159(5)
Acute Respiratory Distress Syndrome
164(1)
Pulmonary Embolism
165(3)
Bronchitis
168(1)
Bronchiectasis and Atelectasis
169(4)
Obstructive Airway Diseases
173(7)
Occupational Lung Diseases
180(5)
Allergic Diseases of the Lungs
185(5)
Infiltrative Lung Diseases
190(4)
Pneumonia
194(6)
Lung Abscess
200(1)
Cystic Fibrosis
201(4)
Pleural Disorders
205(4)
Lung Cancer
209(4)
Section 5 Bone, Joint, and Muscle Disorders 213(64)
Bones, Joints, and Muscles
214(4)
Osteoporosis
218(3)
Paget's Disease of Bone
221(1)
Bone Tumors
222(2)
Osteoarthritis
224(2)
Disorders of Joints and Connective Tissue
226(18)
Gout and Pseudogout
244(2)
Bone and Joint Infections
246(2)
Charcot's Joints
248(1)
Disorders of Muscles, Bursas, and Tendons
249(5)
Foot Problems
254(7)
Sports Injuries
261(11)
Exercise and Fitness
272(5)
Section 6 Brain and Nerve Disorders 277(110)
Biology of the Nervous System
278(4)
Neurologic Examination and Tests
282(6)
Pain
288(6)
Headaches
294(4)
Vertigo
298(2)
Sleep Disorders
300(6)
Muscle Weakness
306(2)
Muscular Dystrophy and Related Disorders
308(3)
Movement Disorders
311(7)
Multiple Sclerosis and Related Disorders
318(4)
Spinal Cord Disorders
322(8)
Peripheral Nerve Disorders
330(10)
Cranial Nerve Disorders
340(2)
Smell and Taste Disorders
342(3)
Seizure Disorders
345(5)
Storke and Related Disorders
350(7)
Head Injuries
357(7)
Delirium and Dementia
364(5)
Stupor and Coma
369(3)
Infections of the Brain and Spinal Cord
372(6)
Tumors of the Nervous System
378(9)
Section 7 Mental Health Disorders 387(68)
Overview of Mental Health Care
388(2)
Psychosomatic Disorders
390(2)
Somatoform Disorders
392(3)
Anxiety Disorders
395(7)
Depression and Mania
402(9)
Suicidal Behavior
411(4)
Eating Disorders
415(2)
Sexuality and Psychosexual Disorders
417(4)
Disorders of Sexual Function
421(5)
Personality Disorders
426(4)
Dissociative Disorders
430(5)
Schizophrenia and Delusional Disorder
435(5)
Drug Dependence and Addiction
440(15)
Section 8 Mouth and Dental Disorders 455(24)
Disorders of the Lips, Mouth, and Tongue
455(6)
Tooth Disorders
461(6)
Periodontal Diseases
467(3)
Disorders of the Temporomandibular Joint
470(4)
Urgent Dental Problems
474(2)
Cancer and Other Growths of the Mouth
476(3)
Section 9 Digestive Disorders 479(76)
Biology of the Digestive System
480(4)
Diagnostic Tests for Digestive Disorders
484(3)
Disorders of the Esophagus
487(7)
Disorders of the Stomach and Duodenum
494(6)
Disorders of the Anus and Rectum
500(4)
Disorders of the Pancreas
504(7)
Indigestion
511(3)
Gastroenteritis
514(7)
Bowel Movement Disorders
521(6)
Inflammatory Bowel Diseases
527(6)
Antibiotic-Associated Colitis
533(1)
Malabsorption Syndromes
534(4)
Diverticular Disease
538(3)
Gastrointestinal Emergencies
541(8)
Cancer and Other Growths of the Digestive System
549(6)
Section 10 Liver and Gallbladder Disorders 555(30)
Biology of the Liver and Gallbladder
555(2)
Diagnostic Tests for Liver and Gallbladder Disorders
557(3)
Clinical Manifestations of Liver Disease
560(6)
Fatty Liver, Cirrhosis, and Related Disorders
566(5)
Hepatitis
571(3)
Blood Vessel Disorders of the Liver
574(3)
Liver Tumors
577(3)
Gallbladder Disorders
580(5)
Section 11 Kidney and Urinary Tract Disorders 585(56)
Biology of the Kidneys and Urinary Tract
586(7)
Kidney Failure
593(8)
Nephritis
601(7)
Blood Vessel Disorders of the Kidneys
608(5)
Metabolic and Congenital Kidney Disorders
613(7)
Urinary Tract Infections
620(5)
Urinary Tract Obstruction
625(4)
Neurogenic Bladder
629(2)
Urinary Incontinence
631(4)
Injury to the Urinary Tract
635(2)
Kidney and Urinary Tract Tumors and Cancers
637(4)
Section 12 Disorders of Nutrition and Metabolism 641(52)
Overview of Nutrition
642(2)
Malnutrition
644(6)
Vitamins and Minerals
650(14)
Water Balance
664(2)
Salt Balance
666(10)
Acid-Base Balance
676(3)
Disorders of Cholesterol and Other Fats
679(6)
Obesity
685(2)
Porphyrias
687(3)
Amyloidosis
690(3)
Section 13 Hormonal Disorders 693(40)
Endocrine System and Hormones
693(3)
Pituitary Gland Disorders
696(8)
Thyroid Gland Disorders
704(8)
Adrenal Gland Disorders
712(5)
Diabetes Mellitus
717(7)
Hypoglycemia
724(2)
Multiple Endocrine Neoplasia Syndromes
726(3)
Polyglandular Deficiency Syndromes
729(1)
Carcinoid
730(3)
Section 14 Blood Disorders 733(56)
Biology of Blood
734(4)
Blood Transfusion
738(4)
Anemias
742(9)
Bleeding Disorders
751(10)
White Blood Cell Disorders
761(4)
Leukemias
765(5)
Lymphomas
770(9)
Plasma Cell Disorders
779(3)
Myeloproliferative Disorders
782(3)
Spleen Disorders
785(4)
Section 15 Cancer 789(18)
Causes and Risks of Cancer
789(3)
Cancer and the Immune System
792(2)
Diagnosis of Cancer
794(3)
Complications of Cancer
797(2)
Cancer Treatment
799(8)
Section 16 Immune Disorders 807(32)
Biology of the Immune System
807(9)
Immunodeficiency Disorders
816(7)
Allergic Reactions
823(9)
Transplantation
832(7)
Section 17 Infections 839(110)
Biology of Infectious Disease
840(5)
Immunizations to Prevent Infection
845(2)
Anti-infective Drugs
847(6)
Infections of the Skin and Underlying Tissue
853(3)
Abscesses
856(3)
Bacteremia and Septic Shock
859(2)
Bacillary Infections
861(12)
Coccal Infections
873(5)
Spirochetal Infections
878(4)
Anaerobic Bacterial Infections
882(3)
Tuberculosis
885(6)
Leprosy
891(2)
Rickettsial Infections
893(2)
Parasitic Infections
895(13)
Fungal Infections
908(4)
Viral Infections
912(14)
Human Immunodeficiency Vinus Infection
926(7)
Infection in People With Impaired Defenses
933(4)
Sexually Transmitted Diseases
937(12)
Section 18 Skin Disorders 949(46)
Biology of the Skin
950(2)
Topical Skin Medications
952(3)
Itching
955(1)
Superficial Skin Disorders
955(4)
Dermatitis
959(5)
Skin Inflammation
964(3)
Blistering Diseases
967(2)
Bedsores
969(1)
Sweating Disorders
970(2)
Sebaceous Gland Disorders
972(3)
Hair Disorders
975(1)
Bacterial Skin Infections
976(3)
Fungal Skin Infections
979(3)
Parasitic Skin Infections
982(2)
Viral Skin Infections
984(1)
Sunlight and Skin Damage
985(3)
Pigment Disorders
988(1)
Noncancerous Skin Growths
989(3)
Skin Cancers
992(3)
Section 19 Ear, Nose, and Throat Disorders 995(30)
Ears, Nose, and Throat
995(3)
Hearing Loss and Deafness
998(4)
Outer Ear Disorders
1002(2)
Middle and Inner Ear Disorders
1004(9)
Disorders of the Nose and Sinuses
1013(4)
Throat Disorders
1017(5)
Head and Neck Cancers
1022(3)
Section 20 Eye Disorders 1025(30)
Eyes and Vision
1026(2)
Refractive Disorders
1028(3)
Eye Injuries
1031(2)
Eye Socket Disorders
1033(1)
Eyelid and Tear Gland Disorders
1034(3)
Disorders of the Conjunctiva
1037(3)
Corneal Disorders
1040(2)
Cataracts
1042(2)
Disorders of the Uvea
1044(1)
Retinal Disorders
1045(4)
Glaucoma
1049(2)
Optic Nerve Disorders
1051(4)
Section 21 Men's Health Issues 1055(12)
Male Reproductive System
1055(2)
Disorders of the Penis, Prostate, and Testes
1057(8)
Impotence
1065(2)
Section 22 Women's Health Issues 1067(122)
Female Reproductive System
1068(6)
Hormones and Reproduction
1074(3)
Menopause
1077(3)
Common Gynecologic Problems
1080(7)
Absent or Abnormal Uterine Bleeding
1087(4)
Polycystic Ovary Syndrome
1091(1)
Endometriosis
1092(3)
Breast Disorders
1095(13)
Cancers of the Female Reproductive System
1108(6)
Intertility
1114(5)
Family Planning
1119(10)
Tests for Genetic Disorders
1129(7)
Pregnancy
1136(9)
High-Risk Pregnancy
1145(7)
Complications of Pregnancy
1152(8)
Diseases That Can Complicate Pregnancy
1160(7)
Drug Use During Pregnancy
1167(5)
Labor and Delivery
1172(6)
Complications of Labor and Delivery
1178(6)
Postdelivery Period
1184(5)
Section 23 Children's Health Issues 1189(146)
Normal Newborns and Infants
1190(11)
Problems in Newborns and Infants
1201(15)
Infections in Newborns and Infants
1216(7)
Birth Defects
1223(17)
Mental Retardation
1240(3)
Sick Children and Their Families
1243(2)
Developmental Problems in Young Children
1245(9)
Puberty and Problems in Adolescents
1254(5)
Bacterial Infections
1259(7)
Viral Infections
1266(9)
Human Immunodeficiency Virus Infection
1275(3)
Pinworm Infection
1278(1)
Disorders Likely Caused by Infection
1279(4)
Childhood Cancers
1283(2)
Gastrointestinal Disorders
1285(3)
Nutritional Disorders
1288(2)
Metabolic Disorders
1290(4)
Hormonal Disorders
1294(6)
Musculoskeletal Disorders
1300(11)
Cerebral Palsy
1311(2)
Ear, Nose, and Throat Disorders
1313(1)
Eye Disorders
1314(1)
Mental Health Disorders
1315(7)
Child Abuse and Neglect
1322(1)
Poisoning
1323(6)
Injuries
1329(6)
Section 24 Accidents and Injuries 1335(32)
Burns
1335(3)
Electrical Injuries
1338(2)
Radiation Injury
1340(4)
Heat Disorders
1344(1)
Cold Injuries
1345(2)
Mountain Sickness
1347(2)
Near Drowning
1349(1)
Diving Injuries
1350(6)
Air Travel and Medical Problems
1356(2)
Poisoning
1358(3)
Venomous Bites and Stings
1361(6)
Appendixes 1367(36)
I. Legal Issues
1367(4)
II. Weights and Measures
1371(3)
III. Common Medical Tests
1374(7)
IV. Some Trade Names of Generic Drugs
1381(7)
V. Resources for Help and Information
1388(15)
Index 1403

Excerpts

Air Travel and Medical Problems

Traveling by air can cause or worsen a variety of medical conditions, although very few conditions would prevent a person from flying. Those that may prevent flying include a pneumothorax, lung damage from tuberculosis, diseases that could be spread to other passengers, and conditions in which even a small expansion of air would damage tissues, such as intestinal surgery in the previous 10 days. Some conditions require planning and taking precautions before a flight. For example, people who have had a colostomy should wear a large bag and anticipate frequent filling.

Air travel poses problems related to changes in air pressure, reduced amounts of oxygen, turbulence, disruptions of the body's internal 24-hour (circadian) clock (jet lag), and psychologic or physical stress.

Changes in Air Pressure

Modern jet airplanes maintain air pressure inside the cabin (cabin pressure) at low levels, equivalent to the atmospheric pressure at 5,000 to 8,000 feet. At such levels, air trapped in pockets within the body - such as in the lungs, inner ear, sinuses, and intestinal tract - expands by about 25 percent. This expansion sometimes aggravates certain medical conditions, such as emphysema, blocked eustachian tubes, chronic sinusitis, and chronic gas pains. Problems may be particularly severe when an airplane accidentally loses cabin pressure or when the cabin isn't pressurized, as is the case with some smaller airplanes.

A sensation of pressure in the ears is common during airplane flights. It develops as the difference between pressure outside the ear and inside the ear increases, causing the eardrum to bulge. Eventually, the pressure equalizes when the eustachian tube (a passage that connects the middle ear with the back of the nose) allows air to flow in and out of the middle ear. Head colds or allergies may produce fluid and swelling that block the eustachian tube, and repeated infections may result in scarring that partially blocks it. Then air becomes trapped in the middle ear, producing pressure (barotitis media) and pain. Rarely, the eardrum ruptures. Similarly, air may be trapped in the sinuses (barosinusitis), causing facial pain.

Swallowing frequently or yawning during the airplane's descent and taking decongestants before or during the flight can prevent or relieve these conditions. Because children are particularly susceptible to barotitis media, they should chew gum, suck hard candy, or drink something during ascent and descent to encourage swallowing; babies can be nursed or given a bottle or pacifier.

Reduced Oxygen

The relatively low air pressure inside an airplane also causes problems because of its effect on oxygen levels. Low oxygen levels are particularly troublesome for people who have a severe lung disease such as emphysema or cystic fibrosis, heart failure, severe anemia, severe angina, sickle cell disease, or certain congenital heart diseases. Usually, such people can fly safely if provided with oxygen. Airlines can handle a request for oxygen if notified 72 hours in advance of a flight. People generally may fly 10 to 14 days after a heart attack. During flight, people who have breathing problems should not smoke or drink alcohol - which aggravates the effects of reduced oxygen. In general, anyone who can walk 100 yards or climb one flight of stairs should be able to tolerate normal cabin conditions without additional oxygen.

Turbulence

Turbulence can cause air sickness or an injury. People who are prone to air sickness may benefit from dimenhydrinate taken as a tablet or scopolamine applied to the skin as a patch. However, these drugs may cause adverse effects, particularly in the elderly The patches cause fewer adverse effects. To prevent injuries, passengers should keep their seat belts fastened while seated.

Jet Lag

Rapid travel across several time zones produces many physical and psychologic stresses known as jet lag (circadian dysrhythmia). A gradual shift in eating and sleeping patterns before departure may alleviate the problem. Some medication schedules may have to be adjusted; for example, the intervals between drugs normally taken at precise times throughout the day should be based on elapsed time - - such as every 8 hours -rather than on local time. People who have diabetes and who use long-acting insulin may switch to regular insulin until they've adjusted to the new time zone, food, and activity level, or they may make up the difference in time zone changes over several days. They should work out a medication and eating schedule with their doctor before departure and take with them a device to monitor blood sugar (glucose) levels.

Melatonin, a hormone that regulates the sleepwake cycle, is reported to help with sleep disturbances caused by jet lag. Its effectiveness depends on taking the doses on a precise schedule.

Because melatonin products are nutritional supplements rather than prescription drugs, the claims made by the manufacturers have not undergone rigorous scrutiny, and the quality of each formulation may vary.

Psychologic Stress

Fear of flying and claustrophobia can cause distress. Hypnosis and behavior modification help some people. Taking a sedative may relieve fears before and during a flight.

Because the behavior of some mentally ill people worsens during airplane flights, those with violent or unpredictable tendencies must be accompanied by an attendant, and they may need to take a sedative before the flight.

General Precautions

Cardiac pacemakers and metal artificial limbs, plates, or pins are affected by airport metal detectors used to scan for concealed weapons; however, newer models of pacemakers can withstand potential interference from such detectors. To avoid security problems, people who wear such devices should carry a doctor's note explaining the situation.

The risk of developing blood clots in the legs is increased in anyone who sits in one place for a long time. Pregnant women and people who have poor circulation are at particular risk. Walking around the airplane cabin every hour or two and contracting and relaxing the leg muscles while sitting help keep the blood flowing.

Dehydration, resulting from the low humidity (about 5 percent) in the cabin, can be prevented by drinking enough liquids and avoiding alcohol, which makes dehydration worse. People who wear contact lenses should apply rewetting solution to their lenses frequently to combat the effects of dry air.

Special foods, including low-salt, low-fat, and diabetic diets, are usually available from an airline by advance request.

Travelers should pack drugs in a carry-on bag rather than in a suitcase checked at the airport, in case their luggage is lost, stolen, or delayed. Drugs should be kept in their original containers. Travelers who must carry narcotics, large amounts of any drug, or syringes should have a doctor's note to avoid being detained by security or customs officers. Travelers may wish to carry a summary of their medical records, including electrocardiogram results, in case they become ill while away from home. Those who have a potentially disabling condition, such as epilepsy, should wear a Medic Alert identification bracelet or necklace.

Women with normal pregnancies can travel by air through the eighth month. Women with highrisk pregnancies should discuss their travel plans with their doctor and obtain approval before flying. Generally, air travel during the ninth month requires a doctor's note dated within 72 hours of departure and indicating the woman's anticipated date of delivery. Seat belts should be worn low across the thighs, not over the abdomen, to prevent injury to the uterus.

Infants under 7 days old aren't permitted to fly. Children with chronic diseases, such as congenital heart or lung diseases or anemia, have the same restrictions as adults with those conditions. There's no upper age limit for travel.

Airlines make reasonable efforts to accommodate the handicapped. Often, wheelchairs and stretchers can be accommodated on commercial flights; otherwise, air ambulance service is necessary. Some airlines accept people who need special equipment such as intravenous lines and mechanical respirators as long as trained personnel accompany them and arrangements have been made at least 72 hours in advance.

Information and advice about air travel can be obtained from the medical departments of major airlines or from the Federal Aviation Administration Regional Flight Surgeon.

Foreign Travel

Of the millions of people who travel or work abroad every year, about I out of 30 needs medical attention for an illness or injury. Gastrointestinal infections may result from drinking contaminated water, including ice, and beverages or eating uncooked or improperly cooked foods. Casual sexual contacts produce a high risk for contracting the human immunodeficiency virus (HIV), which exists worldwide, as well as other sexually transmitted diseases. Motor vehicle accidents, especially at night, and drowning are the leading causes of death or injury for travelers in foreign countries. Health risks vary according to country and region; the Centers for Disease Control and Prevention provides up-to-date health advisories.

In foreign countries, many insurance plans, including Medicare, are not valid, and hospitals often require a substantial cash deposit, regardless of health insurance held in the United States. A variety of travel insurance plans, including some that arrange for emergency evacuation, are available through travel agents and some credit card companies. Directories listing English-speaking doctors in foreign countries are available from several organizations, and United States consulates may help secure emergency medical services.

Vaccinations

People planning a trip to another country should have the appropriate vaccinations, depending on their destination. In general, more preparation is needed when the trip lasts longer than 3 weeks, has several destinations in developing countries, or involves travel in rural areas or working with resident populations. Requirements for vaccinations change frequently. Some vaccinations must be given 2 to 12 weeks before the trip, so a traveler should inquire about vaccinations in advance. Information about vaccination requirements is available from various sources.

(Continues...)

Excerpted from The Merck Manual Of Medical Information by Robert Berkow Copyright © 1997 by Merck & Co., Inc.
Excerpted by permission. All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.

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